产品名称
HSL Phospho-Ser660 Rabbit Polyclonal Antibody
别名
Hormone-sensitive lipase (HSL) (EC 3.1.1.79)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3991
Human Swissprot No.
Q05469
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q05469/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16890
Mouse Swissprot No.
P54310
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P54310
Rat Gene Link
https://www.uniprot.org/uniprot/25330
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P15304
特异性
This antibody detects endogenous levels of HSL Ser660 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane . Membrane, caveola . Cytoplasm, cytosol . Lipid droplet . Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity). .
功能
catalytic activity:Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.,catalytic activity:Monoacylglycerol + H(2)O = glycerol + a carboxylate.,catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,enzyme regulation:Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.,function:In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.,pathway:Glycerolipid metabolism; triacylglycerol degradation.,similarity:Belongs to the 'GDXG' lipolytic enzyme family.,subcellular location:Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.,subunit:Interacts with PTRF in the adipocyte cytoplasm.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
