BD-PP1797

MDA5 Phospho-ser828 Rabbit Polyclonal Antibody

Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)

常规抗体

IFIH1 MDA5 RH116

MDA5 ser828

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

64135

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64135

Q9BYX4

https://www.uniprot.org/uniprotkb/Q9BYX4/entry

71586

https://www.uniprot.org/uniprot/71586

Q8R5F7

https://www.uniprot.org/uniprotkb/Q8R5F7

https://www.uniprot.org/uniprotkb/0

This antibody detects endogenous levels of MDA5 ser828 at Human, Mouse,Rat

WB 1:500-2000

113kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.

Cytoplasm . Nucleus . Mitochondrion . Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis.

disease:Genetic variation in IFIH1 is associated with insulin-dependent diabetes mellitus 19 (IDDM19) [MIM:610155].,function:RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.,induction:By IFN-beta and TNF-alpha.,miscellaneous:In HIV-1 infected HeLa-CD4 cells, overexpression of IFIH1 results in a great increase in the level of secreted viral p24 protein.,PTM:During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 CARD domains.,subcellular location:May be found in the nucleus, during apoptosis.,subunit:Interacts with MAVS. Interacts with V protein of Simian virus 5, Human parainfluenza virus 2, Mumps virus, Sendai virus and Hendra virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state.,tissue specificity:Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.,

现货

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.