产品名称
lipin1 Phospho-ser889 Rabbit Polyclonal Antibody
别名
Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23175
Human Swissprot No.
Q14693
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14693/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14245
Mouse Swissprot No.
Q91ZP3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91ZP3
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of lipin1 ser889 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.
细胞定位
Cytoplasm, cytosol . Endoplasmic reticulum membrane . Nucleus membrane . Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5. .
功能
disease:Defects in LPIN1 are a cause of autosomal recessive acute recurrent myoglobinuria [MIM:268200]; also known as acute recurrent rhabdomyolysis. Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. Onset is usually in early childhood under the age of 5 years.,function:Is involved in adipocyte differentiation.,miscellaneous:May represents a candidate gene for human lipodysytropy syndromes.,similarity:Belongs to the lipin family.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
