产品名称
EDEM3 Rabbit Polyclonal Antibody
蛋白名称
ER degradation-enhancing alpha-mannosidase-like 3
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BZQ6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZQ6/entry
Mouse Swissprot No.
Q2HXL6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q2HXL6
免疫原
Synthesized peptide derived from part region of human protein
特异性
EDEM3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008],
组织表达
Brain,Liver,Lung,Placenta,Testis,Whole embr
细胞定位
Endoplasmic reticulum lumen .
功能
domain:Contains a protease-associated domain (PA) of unknown function.,function:Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.,PTM:N-glycosylated.,similarity:Belongs to the glycosyl hydrolase 47 family.,similarity:Contains 1 PA (protease associated) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
