产品名称
NACA (Phospho-Thr159) Rabbit Polyclonal Antibody
别名
Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)
蛋白名称
NACA (Phospho-Thr159)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4666
Human Swissprot No.
Q13765
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13765/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17938
Mouse Swissprot No.
Q60817
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60817
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of NACA (Phospho-Thr159) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm . Nucleus . The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. .
功能
allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,function:Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.,PTM:Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the NAC-alpha family.,similarity:Contains 1 NAC-A/B (NAC-alpha/beta) domain.,similarity:Contains 1 UBA domain.,subcellular location:Predominantly cytoplasmic. Also found in nucleus.,subunit:Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains. Interacts with ASFV protein H339R.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
