产品名称
EDC4 Rabbit Polyclonal Antibody
蛋白名称
Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6P2E9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P2E9/entry
Mouse Swissprot No.
Q3UJB9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UJB9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q3ZAV8
免疫原
Synthesized peptide derived from part region of human protein
特异性
EDC4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the WD repeat EDC4 family.,similarity:Contains 4 WD repeats.,subunit:Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2.,
组织表达
Duodenum,Epithelium,Skin,Testis,Trachea,
细胞定位
Cytoplasm, P-body . Nucleus .
功能
function:In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the WD repeat EDC4 family.,similarity:Contains 4 WD repeats.,subunit:Part of a decapping complex consisting of DCP1A, DCP2, EDC3, EDC4 and probably DDX6. Part of a complex consisting of DCP1A, EDC3, EDC4 and DDX6. Part of a complex consisting of DCP1B, EDC3, EDC4 and DDX6. Interacts with DCP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
