产品名称
Shc3 (Phospho-Tyr424) Rabbit Polyclonal Antibody
别名
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
蛋白名称
Shc3 (Phospho-Tyr424)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53358
Human Swissprot No.
Q92529
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92529/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20418
Mouse Swissprot No.
Q61120
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61120
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O70143
特异性
This antibody detects endogenous levels of Shc3 (Phospho-Tyr424) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
细胞定位
cytosol,plasma membrane,
功能
function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
