产品名称
MAZ (Phospho-Thr72) Rabbit Polyclonal Antibody
别名
Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4150
Human Swissprot No.
P56270
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P56270/entry
Mouse Swissprot No.
P56671
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P56671
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of MAZ (Phospho-Thr72) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). ; [Isoform 1]: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle and weakly expressed in the kidney (PubMed:1502157). Expressed in the joint synovium (PubMed:19583771).
细胞定位
Nucleus . In brains of Alzheimer disease patients, present in a plaque-like structures.
功能
function:May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the c-myc promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.,similarity:Contains 6 C2H2-type zinc fingers.,subcellular location:In brains of Alzheimer disease patients, present in a plaque-like structures.,subunit:Interacts with BPTF.,tissue specificity:Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
