产品名称
STF-1 (Phospho-Ser203) Rabbit Polyclonal Antibody
别名
Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)
基因名称
NR5A1 AD4BP FTZF1 SF1
蛋白名称
STF-1 (Phospho-Ser203)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2516
Human Swissprot No.
Q13285
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13285/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26423
Mouse Swissprot No.
P33242
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P33242
Rat Gene Link
https://www.uniprot.org/uniprot/83826
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P50569
特异性
This antibody detects endogenous levels of STF-1 (Phospho-Ser203) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).
功能
disease:Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.,disease:Defects in NR5A1 are a cause of XY sex reversal with or without adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus.,function:Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3.,PTM:Acetylation stimulates the transcriptional activity.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR5 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Binds DNA as a monomer. Interacts with NR0B2 and PPARGC1A (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1/SF-1. Interacts with NCOA2.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
