产品名称
Smad1/5/9 (Phospho-Ser463+Ser465) Rabbit Polyclonal Antibody
别名
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
基因名称
SMAD1 BSP1 MADH1 MADR1
蛋白名称
Smad1/5/9 (Phospho-Ser463+Ser465)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4086
Human Swissprot No.
Q15797/Q99717/O15198
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15797/entry
Mouse Gene ID
17125/17129/55994
Mouse Gene Link
https://www.uniprot.org/uniprot/17125
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59328
Rat Swissprot No.
P97588/Q9R1V3/O54835
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97588
特异性
This antibody detects endogenous levels of Smad1/5/9 (Phospho-Ser463+Ser465) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest expression seen in the heart and skeletal muscle.
细胞定位
Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .
功能
function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
