产品名称
EPHB1/2/3/4 (Phospho-Tyr600/602/614/596) Rabbit Polyclonal Antibody
别名
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
基因名称
EPHB1 ELK EPHT2 HEK6 NET
蛋白名称
EPHB1/2/3/4 (Phospho-Tyr600/602/614/596)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2047
Human Swissprot No.
P54762
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P54762/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/270190
Mouse Swissprot No.
Q8CBF3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CBF3
Rat Gene Link
https://www.uniprot.org/uniprot/24338
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P09759
特异性
This antibody detects endogenous levels of EPHB1/2/3/4 (Phospho-Tyr600/602/614/596) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Preferentially expressed in brain.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP.,tissue specificity:Preferentially expressed in brain.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
