产品名称
CRMP-1 (Phospho-Tyr504) Rabbit Polyclonal Antibody
别名
Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3)
蛋白名称
CRMP-1 (Phospho-Tyr504)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1400
Human Swissprot No.
Q14194
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14194/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12933
Mouse Swissprot No.
P97427
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97427
Rat Gene Link
https://www.uniprot.org/uniprot/25415
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62950
特异性
This antibody detects endogenous levels of CRMP-1 (Phospho-Tyr504) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cell projection, growth cone . Cytoplasm, cytoskeleton . Perikaryon . Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). .
功能
function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subcellular location:Associated with centrosomes and the mitotic spindle during metaphase.,subunit:Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1.,tissue specificity:Brain.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
