产品名称
NDRG2 (Phospho-Thr348) Rabbit Polyclonal Antibody
别名
Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613)
蛋白名称
NDRG2 (Phospho-Thr348)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57447
Human Swissprot No.
Q9UN36
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UN36/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/29811
Mouse Swissprot No.
Q9QYG0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYG0
Rat Gene Link
https://www.uniprot.org/uniprot/171114
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VBU2
特异性
This antibody detects endogenous levels of NDRG2 (Phospho-Thr348) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
细胞定位
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone . In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). .
功能
developmental stage:Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.,disease:Found in pathological brain lesions of Alzheimer disease.,disease:Not expressed or strongly down-regulated in various cancer types, such as astrocytoma, meningioma, liver cancer and pancreatic cancer.,function:May be involved in dendritic cell and neuron differentiation. May have anti-tumor activity.,similarity:Belongs to the NDRG family.,subcellular location:Perinuclear in neurons.,tissue specificity:Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Generally not expressed in tumor cell lines. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
