产品名称
NDR1/2 (Phospho-Thr444/442) Rabbit Polyclonal Antibody
别名
Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
蛋白名称
NDR1/2 (Phospho-Thr444/442)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11329
Human Swissprot No.
Q15208
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15208/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/106504
Mouse Swissprot No.
Q91VJ4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VJ4
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of NDR1/2 (Phospho-Thr444/442) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Low levels present in the cytoplasm.,subunit:Homodimeric S100B binds two molecules of STK38. Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
