产品名称
XRCC1 (Phospho-Thr284) Rabbit Polyclonal Antibody
别名
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
蛋白名称
XRCC1 (Phospho-Thr284)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7515
Human Swissprot No.
P18887
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P18887/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22594
Mouse Swissprot No.
Q60596
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60596
Rat Gene Link
https://www.uniprot.org/uniprot/84495
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ESZ0
特异性
This antibody detects endogenous levels of XRCC1 (Phospho-Thr284) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
细胞定位
Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
功能
function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
