产品名称
BAG3 (Phospho-Tyr457) Rabbit Polyclonal Antibody
别名
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
蛋白名称
BAG3 (Phospho-Tyr457)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9531
Human Swissprot No.
O95817
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95817/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/29810
Mouse Swissprot No.
Q9JLV1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLV1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of BAG3 (Phospho-Tyr457) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain,Epithelium,Liver,Lung,Placenta,T-cell,Testis,Tongue,
细胞定位
Nucleus . Cytoplasm . Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). .
功能
function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.,similarity:Contains 1 BAG domain.,similarity:Contains 2 WW domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
