BD-PN0697

ELP3 Rabbit Polyclonal Antibody

常规抗体

ELP3

Elongator complex protein 3 (hELP3) (EC 2.3.1.48)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

55140

Q9H9T3

https://www.uniprot.org/uniprotkb/Q9H9T3/entry

Q9CZX0

http://www.uniprot.org/uniprot/Q9CZX0

Synthesized peptide derived from part region of human protein

ELP3 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

60kD

-20°C/1 year

Polyclonal, Rabbit,IgG

ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009],

Expressed in the cerebellum and spinal motor neurons.

Cytoplasm . Nucleus .; [Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . Nucleus .

catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,cofactor:Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,function:Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity.,similarity:Belongs to the ELP3 family.,similarity:Contains 1 N-acetyltransferase domain.,subunit:Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. IKBKAP/ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with IKBKAP/ELP1.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.