产品名称
eIF2B-ε (Phospho-Ser540) Rabbit Polyclonal Antibody
别名
Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)
蛋白名称
eIF2B-ε (Phospho-Ser540)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8893
Human Swissprot No.
Q13144
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13144/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/224045
Mouse Swissprot No.
Q8CHW4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CHW4
Rat Gene Link
https://www.uniprot.org/uniprot/192234
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q64350
特异性
This antibody detects endogenous levels of eIF2B-ε (Phospho-Ser540) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain,Epithelium,Hepatocyte,Lung,Platelet,
细胞定位
nucleus,cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex,
功能
disease:Defects in EIF2B5 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.,function:Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.,similarity:Belongs to the EIF-2B gamma/epsilon subunits family.,similarity:Contains 1 W2 domain.,subunit:Complex of five different subunits; alpha, beta, gamma, delta and epsilon.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
