产品名称
NuaK1 (Phospho-Ser600) Rabbit Polyclonal Antibody
别名
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
基因名称
NUAK1 ARK5 KIAA0537 OMPHK1
蛋白名称
NuaK1 (Phospho-Ser600)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9891
Human Swissprot No.
O60285
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60285/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/77976
Mouse Swissprot No.
Q641K5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q641K5
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of NuaK1 (Phospho-Ser600) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines.
细胞定位
Nucleus . Cytoplasm .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by PKB/AKT1 during glucose starvation. Activated by phosphorylation on Thr-211 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
