产品名称
CAMKK1/2 (Phospho-Ser458/495) Rabbit Polyclonal Antibody
别名
Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
蛋白名称
CAMKK1/2 (Phospho-Ser458/495)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84254
Human Swissprot No.
Q8N5S9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N5S9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/55984
Mouse Swissprot No.
Q8VBY2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VBY2
Rat Gene Link
https://www.uniprot.org/uniprot/60341
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97756
特异性
This antibody detects endogenous levels of CAMKK1/2 (Phospho-Ser458/495) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.,domain:The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.,function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.,PTM:Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with CAMK4 and calmodulin.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
