产品名称
XPA (Phospho-Ser196) Rabbit Polyclonal Antibody
别名
DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)
蛋白名称
XPA (Phospho-Ser196)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7507
Human Swissprot No.
P23025
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23025/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22590
Mouse Swissprot No.
Q64267
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64267
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of XPA (Phospho-Ser196) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in various cell lines and in skin fibroblasts.
功能
disease:Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.,function:Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the XPA family.,subunit:Interacts with XAB1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation.,tissue specificity:Expressed in various cell lines and in skin fibroblasts.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
