产品名称
LAB (Phospho-Tyr136) Rabbit Polyclonal Antibody
别名
Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)
基因名称
LAT2 LAB NTAL WBS15 WBSCR15 WBSCR5 HSPC046
蛋白名称
LAB (Phospho-Tyr136)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7462
Human Swissprot No.
Q9GZY6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9GZY6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56743
Mouse Swissprot No.
Q9JHL0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHL0
Rat Gene Link
https://www.uniprot.org/uniprot/317676
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CGL2
特异性
This antibody detects endogenous levels of LAB (Phospho-Tyr136) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
细胞定位
Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
功能
disease:Defects in LAT2 may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.,PTM:May be polyubiquitinated.,PTM:Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.,subcellular location:Present in lipid rafts.,subunit:When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.,tissue specificity:Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
