产品名称
ROCK2 (Phospho-Tyr722) Rabbit Polyclonal Antibody
别名
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)
蛋白名称
ROCK2 (Phospho-Tyr722)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9475
Human Swissprot No.
O75116
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75116/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19878
Mouse Swissprot No.
P70336
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70336
Rat Gene Link
https://www.uniprot.org/uniprot/25537
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62868
特异性
This antibody detects endogenous levels of ROCK2 (Phospho-Tyr722) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the brain (at protein level).
细胞定位
Cytoplasm. Cell membrane ; Peripheral membrane protein . Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic, and associated with actin microfilaments and the plasma membrane. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by RHOA binding.,function:Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction.,miscellaneous:Inhibited by Y-27632.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 REM (Hr1) repeat.,subcellular location:Cytoplasmic, and associated with actin microfilaments and the plasma membrane.,subunit:Homodimer. Binds RHOA that has been activated by GTP binding. Binds IRS1, RHOB and RHOC.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
