产品名称
MNK2 (Phospho-Thr244) Rabbit Polyclonal Antibody
别名
MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
蛋白名称
MNK2 (Phospho-Thr244)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2872
Human Swissprot No.
Q9HBH9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HBH9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17347
Mouse Swissprot No.
Q8CDB0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CDB0
Rat Gene Link
https://www.uniprot.org/uniprot/299618
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2N4
特异性
This antibody detects endogenous levels of MNK2 (Phospho-Thr244) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
细胞定位
[Isoform 2]: Nucleus, PML body.; [Isoform 1]: Cytoplasm.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Magnesium.,function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.,PTM:Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2. Isoform 2 interacts with ESR2.,tissue specificity:Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
