产品名称
MAP3K2 (Phospho-Ser520) Rabbit Polyclonal Antibody
别名
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
基因名称
MAP3K2 MAPKKK2 MEKK2
蛋白名称
MAP3K2 (Phospho-Ser520)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10746
Human Swissprot No.
Q9Y2U5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2U5/entry
Mouse Swissprot No.
Q61083
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61083
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of MAP3K2 (Phospho-Ser520) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain,Platelet,T-cell,Teratocarcinoma,Whole embryo,
细胞定位
Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
