产品名称
NTCP2 Rabbit Polyclonal Antibody
基因名称
SLC10A2 ASBT ISBT NTCP2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6555
Human Swissprot No.
Q12908
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12908/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20494
Mouse Swissprot No.
P70172
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70172
Rat Gene Link
https://www.uniprot.org/uniprot/29500
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62633
免疫原
Synthesized peptide derived from human NTCP2 AA range: 46-96
特异性
This antibody detects endogenous levels of NTCP2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010],
细胞定位
Membrane; Multi-pass membrane protein.
功能
disease:Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM) [MIM:601295]. PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels.,function:Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.,similarity:Belongs to the sodium:bile acid symporter family.,subunit:Monomer and homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
