产品名称
PPAR α (Phospho-Ser21) Rabbit Polyclonal Antibody
别名
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
蛋白名称
PPAR α (Phospho-Ser21)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5465
Human Swissprot No.
Q07869
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q07869/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19013
Mouse Swissprot No.
P23204
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P23204
Rat Gene Link
https://www.uniprot.org/uniprot/25747
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P37230
特异性
This antibody detects endogenous levels of PPAR α (Phospho-Ser21) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758).
功能
function:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.,online information:Peroxisome proliferator-activated receptor entry,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13.,tissue specificity:Skeletal muscle, liver, heart and kidney.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
