产品名称
S100A9 (Phospho-Thr113) Rabbit Polyclonal Antibody
别名
Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)
基因名称
S100A9 CAGB CFAG MRP14
蛋白名称
S100A9 (Phospho-Thr113)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6280
Human Swissprot No.
P06702
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P06702/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20202
Mouse Swissprot No.
P31725
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P31725
Rat Gene Link
https://www.uniprot.org/uniprot/94195
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P50116
特异性
This antibody detects endogenous levels of S100A9 (Phospho-Thr113) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.
细胞定位
Secreted. Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein . Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane (PubMed:18786929). Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway (PubMed:15598812). .
功能
function:Expressed by macrophages in acutely inflammated tissues and in chronic inflammations. Seem to be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells.,miscellaneous:Has been shown to bind calcium.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Interacts with CEACAM3 in a calcium-dependent manner.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
