BD-PP1691

Raptor (Phospho-Ser863) Rabbit Polyclonal Antibody

Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)

常规抗体

RPTOR KIAA1303 RAPTOR

Raptor (Phospho-Ser863)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

57521

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57521

Q8N122

https://www.uniprot.org/uniprotkb/Q8N122/entry

Q8K4Q0

https://www.uniprot.org/uniprotkb/Q8K4Q0

https://www.uniprot.org/uniprotkb/0

This antibody detects endogenous levels of Raptor (Phospho-Ser863) at Human, Mouse,Rat

WB 1:500-2000

150kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen.

Cytoplasm. Lysosome. Cytoplasmic granule . Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.

function:Participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). Plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. Has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.,miscellaneous:Rapamycin destabilizes the interaction with FRAP1 regardless of nutrient availability, and its potency for dissociation is increased under nutrient-rich conditions. This action uncouples FRAP1 from its substrates, and inhibits FRAP1 signaling without altering its intrinsic catalytic activity.,similarity:Belongs to the WD repeat RAPTOR family.,similarity:Contains 7 WD repeats.,subunit:Binds directly 4EBP1 and RPS6KB1 independently of its association with FRAP1. Binds preferentially to poorly or non-phosphorylated form of EIF4EBP1, and this binding is critical to the ability of FRAP1 to catalyze phosphorylation. Complex with FRAP1 physically interacts under both leucine-rich and -poor conditions and therefore in at least two nutrient-determined states with different stability.,tissue specificity:Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.,

现货

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.