产品名称
Myd88 (Phospho-Tyr257) Rabbit Polyclonal Antibody
别名
Myeloid differentiation primary response protein MyD88
蛋白名称
Myd88 (Phospho-Tyr257)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4615
Human Swissprot No.
Q99836
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99836/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17874
Mouse Swissprot No.
P22366
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P22366
Rat Gene Link
https://www.uniprot.org/uniprot/301059
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6Y1S1
特异性
This antibody detects endogenous levels of Myd88 (Phospho-Tyr257) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus .
功能
disease:Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also called recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.,function:Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. May be involved in myeloid differentiation.,similarity:Contains 1 death domain.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1 and IRAK2 via their respective TIR domains. Interacts with IL1RL1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
