产品名称
TRI63 Rabbit Polyclonal Antibody
基因名称
TRIM63 IRF MURF1 RNF28 SMRZ
蛋白名称
E3 ubiquitin-protein ligase TRIM63 (EC 6.3.2.-) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q969Q1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q969Q1/entry
Mouse Swissprot No.
Q38HM4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q38HM4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q91Z63
免疫原
Synthesized peptide derived from part region of human protein
特异性
TRI63 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012],
组织表达
Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
细胞定位
Cytoplasm. Nucleus . Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. .
功能
caution:It is uncertain whether Met-1 or Met-14 is the initiator.,developmental stage:Expressed throughout all developmental stages.,domain:The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.,function:E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.,pathway:Protein modification; protein ubiquitination.,sequence caution:Sequencing errors.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 COS domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.,subunit:Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE.,tissue specificity:Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
