产品名称
DYRK1A/B (Phospho-Tyr321/273) Rabbit Polyclonal Antibody
别名
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
基因名称
DYRK1A DYRK MNB MNBH
蛋白名称
DYRK1A/B (Phospho-Tyr321/273)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1859
Human Swissprot No.
Q13627
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13627/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13548
Mouse Swissprot No.
Q61214
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61214
Rat Gene Link
https://www.uniprot.org/uniprot/25255
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63470
特异性
This antibody detects endogenous levels of DYRK1A/B (Phospho-Tyr321/273) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
细胞定位
Nucleus . Nucleus speckle .
功能
alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,developmental stage:Expressed in the developing central nervous system.,disease:Overexpressed 1.5-fold in fetal Down syndrome brain.,enzyme regulation:Inhibited by RANBP9.,function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9.,tissue specificity:Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
