产品名称
CDK4 (Phospho-Thr172) Rabbit Polyclonal Antibody
别名
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
蛋白名称
CDK4 (Phospho-Thr172)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1019
Human Swissprot No.
P11802
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11802/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12567
Mouse Swissprot No.
P30285
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P30285
Rat Gene Link
https://www.uniprot.org/uniprot/94201
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P35426
特异性
This antibody detects endogenous levels of CDK4 (Phospho-Thr172) at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Nucleus membrane . Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:CDK4 mutations are involved in tumor formation.,disease:Defects in CDK4 are the cause of cutaneous malignant melanoma 3 (CMM3) [MIM:609048, 155600]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a preexisting benign nevus, which occurs most often in the skin but also may involve other sites.,enzyme regulation:Phosphorylation at Thr-172 is necessary for enzymatic activity.,function:Probably involved in the control of the cell cycle.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
