产品名称
Cytokeratin 6 (ABT052) Mouse Monoclonal Antibody
别名
CK 6A;CK 6B;CK 6C;CK 6D;CK 6E;CK-6B;CK-6C;CK-6E;Cytokeratin 6a;Cytokeratin 6B;Cytokeratin 6C;Cytokeratin 6D;Cytokeratin 6E;Cytokeratin-6B;Cytokeratin-6C;Cytokeratin-6E;K2C6C_HUMAN;K6a keratin;K6b keratin;K6C;K6c keratin;K6d keratin;K6e keratin;Keratin;Keratin K6h;Keratin type II cytoskeletal 6A;Keratin type II cytoskeletal 6B;Keratin type II cytoskeletal 6C;Keratin type II cytoskeletal 6D;Keratin type II cytoskeletal 6E;Keratin-6C;KRT6A;KRT6B;KRT6C;KRT6D;KRT6E;type II cytoskeletal 6C;Type-II keratin Kb12
蛋白名称
CK 6A;CK 6B;CK 6C;CK 6D;CK 6E;CK-6B;CK-6C;CK-6E;Cytokeratin 6a;Cytokeratin 6B;Cytokeratin 6C;Cytokeratin 6D;Cytokeratin 6E;Cytokeratin-6B;Cytokeratin-6C;Cytokeratin-6E;K2C6C_HUMAN;K6a keratin;K6b keratin;K6C;K6c keratin;K6d keratin;K6e keratin;Keratin;Keratin K6h;Keratin type II cytoskeletal 6A;Keratin type II cytoskeletal 6B;Keratin type II cytoskeletal 6C;Keratin type II cytoskeletal 6D;Keratin type II cytoskeletal 6E;Keratin-6C;KRT6A;KRT6B;KRT6C;KRT6D;KRT6E;type II cytoskeletal 6C;Type-II keratin Kb12
存储缓冲液
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Human Swissprot No.
P02538
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P02538/entry
Mouse Swissprot No.
P50446
特异性
The antibody can specifically recognize human CK6 protein, and shows no cross reaction with CK5. In western blotting of Hela, A431, A549 and HEK293 cell lysates, the antibody can label a 56 kDa band corresponding to CK6 only in A431 cell lysates.
稀释度
IHC-p 1:200-400,WB 500-1000
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasmic, Membranous
功能
allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,disease:Defects in KRT6A are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.,miscellaneous:There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP.,tissue specificity:Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
