产品名称
Claudin 7 (ABT443) Mouse Monoclonal Antibody
别名
CEPTR L2;CEPTRL 2;CEPTRL2;Claudin 1;Claudin 7;Claudin 9;Claudin-7;Claudin1;Claudin7;Claudin9;CLD7_HUMAN;CLDN 7;CLDN-7;CLDN7;Clostridium perfringens enterotoxin receptor like 2;CPETR L2;CPETRL 2;CPETRL2;Hs.84359
基因名称
CLDN7 CEPTRL2 CPETRL2
蛋白名称
CEPTR L2;CEPTRL 2;CEPTRL2;Claudin 1;Claudin 7;Claudin 9;Claudin-7;Claudin1;Claudin7;Claudin9;CLD7_HUMAN;CLDN 7;CLDN-7;CLDN7;Clostridium perfringens enterotoxin receptor like 2;CPETR L2;CPETRL 2;CPETRL2;Hs.84359
存储缓冲液
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Human Swissprot No.
O95471
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95471/entry
Mouse Swissprot No.
Q9Z261
特异性
The antibody can specifically recognize human Claudin 7 protein. In western blotting of LnCap cell lysate, the antibody can label a 22 kDa band corresponding to Claudin 7.. The antibody was also Predict react with Mouse;Rat
稀释度
IHC-p 1:200-400,WB 500-1000
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space.,induction:By androgens.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,tissue specificity:Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
