BD-PN5559

HSC 70 Rabbit Polyclonal Antibody

HSPA8; HSC70; HSP73; HSPA10; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8

常规抗体

HSPA8

Heat shock cognate 71 kDa protein

WB

Human,Mouse,Rat

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

3312

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3312

P11142

http://www.uniprot.org/uniprotkb/P11142/entry

P63017

http://www.uniprot.org/uniprot/P63017

P63018

http://www.uniprot.org/uniprot/O54941P63018

Synthesized peptide derived from the Internal region of human HSC 70. AA range: 588-638

The antibody detects endogenous HSC 70 protein.

WB 1:500 - 1:2000.IHC-p:1:50-300.. IF 1:50-200

70-72kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

Ubiquitous.

Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

Spliceosome;MAPK_ERK_Growth;MAPK_G_Protein;Endocytosis;Antigen processing and presentation;

function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.