产品名称
GβL Rabbit Polyclonal Antibody
别名
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.87% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64223
Human Swissprot No.
Q9BVC4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BVC4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56716
Mouse Swissprot No.
Q9DCJ1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DCJ1
Rat Gene Link
https://www.uniprot.org/uniprot/64226
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2K5
免疫原
Synthesized peptide derived from human GβL AA range: 44-94
特异性
This antibody detects endogenous levels of GβL at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Unessential component of the TORC1 complex and essential component of the TORC2 complex. TORC1 controls cell growth in response to environmental signals, and is inactivated by nutrient limitation and environmental stress. Within TORC1, LST8 interacts directly with FRAP1 and enhances its kinase activity.
组织表达
Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
功能
function:Unessential component of the TORC1 complex and essential component of the TORC2 complex. TORC1 controls cell growth in response to environmental signals, and is inactivated by nutrient limitation and environmental stress. Within TORC1, LST8 interacts directly with FRAP1 and enhances its kinase activity. In nutrient-poor conditions, stabilizes the FRAP1-RAPTOR interaction and favors RAPTOR-mediated inhibition of FRAP1 activity. TORC2 controls polarity of the actin cytoskeleton via the RAC1 pathway. TORC2 mediates phosphorylation of Akt/PKB on 'Ser-473' and phosphorylation of PKCalpha on 'Ser-657'.,similarity:Belongs to the WD repeat LST8 family.,similarity:Contains 7 WD repeats.,subunit:Interacts with FRAP1, RAPTOR and RHEB. Part of the target of rapamycin complex 1 (TORC1) which contains LST8, FRAP1, RAPTOR and AKT1S1. TORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the target of rapamycin complex 2 (TORC2) which contains FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP12-rapamycin.,tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
