产品名称
RN167 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF167 (EC 6.3.2.-) (RING finger protein 167) (RING105)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H6Y7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H6Y7/entry
Mouse Swissprot No.
Q91XF4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91XF4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5XIL0
免疫原
Synthesized peptide derived from part region of human protein
特异性
RN167 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ring finger protein 167(RNF167) Homo sapiens RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008],
组织表达
Strongly expressed in the kidney and liver (at protein level).
细胞定位
Endomembrane system ; Single-pass membrane protein . Targeted to cytoplasmic membranes.
功能
function:May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Targeted to cytoplasmic membranes.,subunit:Interacts with SLC22A18.,tissue specificity:Strongly expressed in the kidney and liver (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
