产品名称
NTHL1 Rabbit Polyclonal Antibody
蛋白名称
Endonuclease III-like protein 1 (EC 4.2.99.18)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P78549
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P78549/entry
Mouse Swissprot No.
O35980
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35980
免疫原
Synthesized peptide derived from part region of human protein
特异性
NTHL1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008],
组织表达
Widely expressed with highest levels in heart and lowest levels in lung and liver.
细胞定位
Nucleus . Mitochondrion .
信号通路
Base excision repair;
功能
catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,caution:It is uncertain whether Met-1, Met-9 or Met-16 is the initiator.,cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,developmental stage:Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase.,function:Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions.,similarity:Belongs to the nth/mutY family.,tissue specificity:Widely expressed with highest levels in heart and lowest levels in lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
