产品名称
ATG7 Rabbit Rabbit Polyclonal Antibody
别名
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7;Autophagy-related protein 7;APG7-like;hAGP7;Ubiquitin-activating enzyme E1-like protein)
蛋白名称
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10533
Human Swissprot No.
O95352
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95352/entry
Mouse Swissprot No.
Q9D906
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D906
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q641Y5
免疫原
Recombinant Protein of ATG7
特异性
The antibody detects endogenous ATG7 protein
稀释度
IHC-p 1:50-300,WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
组织表达
Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
细胞定位
Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
信号通路
Regulation of autophagy;
功能
domain:The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.,function:Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG7 family.,subunit:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
