产品名称
Kv11.3 Rabbit Polyclonal Antibody
别名
Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3;ERG-3;Eag-related protein 3;Ether-a-go-go-related protein 3;hERG-3;Voltage-gated potassium channel subunit Kv11.3)
蛋白名称
Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassium channel subunit Kv11.3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=90134
Human Swissprot No.
Q9NS40
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NS40/entry
Mouse Swissprot No.
Q9ER47
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ER47
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O54852
免疫原
Synthetic Peptide of Kv11.3. AA range 1130-1180
特异性
Kv11.3 protein(A263) detects endogenous levels of Kv11.3
稀释度
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008],
组织表达
Expressed in prolactin-secreting adenomas.
细胞定位
Membrane; Multi-pass membrane protein.
功能
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.,tissue specificity:Expressed in prolactin-secreting adenomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
