产品名称
SLC12A4 Rabbit Polyclonal Antibody
别名
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1;Erythroid K-Cl cotransporter 1;hKCC1)
蛋白名称
Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6560
Human Swissprot No.
Q9UP95
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UP95/entry
Mouse Swissprot No.
Q9JIS8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JIS8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63632
免疫原
Synthetic Peptide of SLC12A4 AA range: 658-708
特异性
SLC12A4 protein(A248) detects endogenous levels of SLC12A4
稀释度
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013],
组织表达
Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
细胞定位
Membrane; Multi-pass membrane protein.
功能
alternative products:Experimental confirmation may be lacking for some isoforms,function:Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.,PTM:N-glycosylated.,similarity:Belongs to the SLC12A transporter family.,subunit:Homomultimer and heteromultimer with other K-Cl cotransporters.,tissue specificity:Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
