产品名称
KCNN2 (SK2) Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3781
Human Swissprot No.
Q6PJI0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6PJI0/entry
免疫原
Synthetic Peptide of KCNN2 (SK2)
特异性
KCNN2(SK2) protein(A244) detects endogenous levels of KCNN2(SK2)
稀释度
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
potassium calcium-activated channel subfamily N member 2(KCNN2) Homo sapiens Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],
组织表达
Brain,Heart,Hippocampus,Myometrium,Skin,
细胞定位
smooth endoplasmic reticulum,plasma membrane,cell surface,integral component of membrane,Z disc,T-tubule,neuronal cell body,dendritic spine,
功能
function:Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.,similarity:Belongs to the potassium channel KCNN family.,subunit:Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.