产品名称
GABA A Receptor α2 Rabbit Polyclonal Antibody
别名
Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)
蛋白名称
Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=282236
Human Swissprot No.
P47869
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P47869/entry
Mouse Swissprot No.
P26048
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P26048
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P23576
免疫原
Synthetic Peptide of GABA A Receptor α2
特异性
GABA A Receptor α2 protein(A224) detects endogenous levels of GABA A Receptor α2
稀释度
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],
细胞定位
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Cell projection, dendrite .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,polymorphism:Genetic variations in GABRA2 determine the genetic susceptibility to alcoholism [MIM:103780].,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
