产品名称
EAAT2 Rabbit Polyclonal Antibody
别名
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
蛋白名称
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6506
Human Swissprot No.
P43004
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P43004/entry
Mouse Swissprot No.
P43006
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P43006
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P31596
免疫原
Synthetic Peptide of EAAT2 AA range: 370-420
特异性
EAAT2 protein(A223) detects endogenous levels of EAAT2
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
组织表达
Brain,Brain cortex,Pancreas,
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Amyotrophic lateral sclerosis (ALS);
功能
function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,subunit:Homotrimer. Interacts with JUB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
