产品名称
CNTF Rabbit Polyclonal Antibody
别名
CNTF; Ciliary neurotrophic factor; CNTF
蛋白名称
Ciliary neurotrophic factor (CNTF)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1270
Human Swissprot No.
P26441
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P26441/entry
Mouse Swissprot No.
P51642
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51642
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P20294
免疫原
Synthetic Peptide of CNTF
特异性
CNTF protein(A218) detects endogenous levels of CNTF
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010],
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29).,function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.,function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis.,online information:Ciliary neurotrophic factor entry,similarity:Belongs to the CNTF family.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Homodimer.,tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.,tissue specificity:Nervous system.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
