BD-PN3734

GRAM4 Rabbit Polyclonal Antibody

常规抗体

GRAMD4 DIP KIAA0767

GRAM4

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

23151

https://www.uniprot.org/uniprot/23151

Q6IC98

https://www.uniprot.org/uniprotkb/Q6IC98/entry

223752

https://www.uniprot.org/uniprot/223752

Q8CB44

https://www.uniprot.org/uniprotkb/Q8CB44

Synthesized peptide derived from human GRAM4 AA range: 304-354

This antibody detects endogenous levels of GRAM4 at Human/Mouse

WB 1：500-2000

64kD

-20°C/1 year

Polyclonal, Rabbit,IgG

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011],

Expressed in lung and in primary lung squamous cell carcinoma (LSCC).

Mitochondrion membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Colocalizes with COX4I1. .

domain:The leucine-zipper is involved in homodimerization.,function:Plays a role as a mediator of e2f1-induced apoptosis in the absence of tp53/p53.,function:Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.,induction:By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells.,induction:Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).,similarity:Belongs to the TSC-22/Dip/Bun family.,similarity:Contains 1 GRAM domain.,subcellular location:Colocalizes with COX4I1.,subunit:Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1.,tissue specificity:Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different haemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.,tissue specificity:Expressed in lung and in primary lung squamous cell carcinoma (LSCC).,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.