BD-PN5679

AMPKβ2 Rabbit Polyclonal Antibody

PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2

常规抗体

PRKAB2

5'-AMP-activated protein kinase subunit beta-2

WB

Human,Mouse,Rat

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

5565

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5565

O43741

http://www.uniprot.org/uniprotkb/O43741/entry

Q6PAM0

http://www.uniprot.org/uniprot/Q6PAM0

Q9QZH4

http://www.uniprot.org/uniprot/O54941Q9QZH4

Recombinant Protein of AMPKβ2

The antibody detects endogenous AMPKβ2 protein.

WB 1:1000-2000

30kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],

Liver,Pancreas,

nucleoplasm,cytosol,nucleotide-activated protein kinase complex,

Insulin_Receptor;Adipocytokine;Hypertrophic cardiomyopathy (HCM);

function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.