产品名称
HAO1 Rabbit Polyclonal Antibody
别名
Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX
蛋白名称
Hydroxyacid oxidase 1
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54363
Human Swissprot No.
Q9UJM8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UJM8/entry
Mouse Swissprot No.
Q9WU19
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WU19
免疫原
Recombinant Protein of HAO1
特异性
The antibody detects endogenous HAO1 protein.
稀释度
WB 1:2000-5000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in liver.
信号通路
Glyoxylate and dicarboxylate metabolism;
功能
catalytic activity:(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).,cofactor:FMN.,function:Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids.,pathway:Organic acid metabolism; glycolic acid degradation; 3-phospho-D-glyceric acid from glycolic acid: step 1/4.,similarity:Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.,similarity:Contains 1 FMN hydroxy acid dehydrogenase domain.,tissue specificity:Liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
