BD-PN5510

MEK-5 Rabbit Polyclonal Antibody

MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5

常规抗体

MAP2K5

Dual specificity mitogen-activated protein kinase kinase 5

WB

Human,Mouse,Rat

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

5067

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5067

Q13163

http://www.uniprot.org/uniprotkb/Q13163/entry

Q9WVS7

http://www.uniprot.org/uniprot/Q9WVS7

Q62862

http://www.uniprot.org/uniprot/O54941Q62862

Recombinant Protein of MEK-5

The antibody detects endogenous MEK-5 protein.

WB 1:1000-2000 IHC 1:200-500. IF 1:50-200

49kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011],

Expressed in many adult tissues. Abundant in heart and skeletal muscle.

nucleus,cytoplasm,spindle,cytosol,

MAPK_ERK_Growth;MAPK_G_Protein;Gap junction;Neurotrophin;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A.,function:Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,PTM:Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.,tissue specificity:Expressed in many adult tissues. Abundant in heart and skeletal muscle.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.