产品名称
L-type Ca++ CP γ5 Rabbit Polyclonal Antibody
别名
CACNG5; Voltage-dependent calcium channel gamma-5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; Transmembrane AMPAR regulatory protein gamma-5; TARP gamma-5
蛋白名称
Voltage-dependent calcium channel gamma-5 subunit
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10369
Human Swissprot No.
Q9UF02
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UF02/entry
Mouse Swissprot No.
Q8VHW4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHW4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VHW8
免疫原
Synthetic Peptide of L-type Ca++ CP γ5 AA range: 110-190
特异性
The antibody detects endogenous L-type Ca++ CP γ5 protein.
稀释度
WB 1:500-1000 IHC 1:100-200. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcium voltage-gated channel auxiliary subunit gamma 5(CACNG5) Homo sapiens The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010],
组织表达
Brain cortex,Thalamus,
细胞定位
Membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
